Altered Expression of Myogenic Regulatory Factors in the Mouse Model of Amyotrophic Lateral Sclerosis

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Altered expression of myogenic regulatory factors in the mouse model of amyotrophic lateral sclerosis.

BACKGROUND In the superoxide dismutase 1 (SOD1)-G93A mouse model of amyotrophic lateral sclerosis (ALS), skeletal muscle is a key target of mutant SOD1 toxicity. However, the expression of factors that control the regenerative potential of the muscle is unknown in this model. OBJECTIVE To characterize the expression of satellite cell marker Pax7 and myogenic regulatory factors (MRF) in skelet...

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ژورنال

عنوان ژورنال: Neurodegenerative Diseases

سال: 2011

ISSN: 1660-2854,1660-2862

DOI: 10.1159/000324159